Atom-efficient synthesis of hybrid molecules combining fragments of triazolopyrimidines and 3-ethoxycarbonyl-1-ethyl-6-fluoroquinolin-4(1H)-one through 1,2,3-triazole linker

An atom-efficient method toward hybrid molecules via azide-alkyne cycloaddition of 7-azido-3-ethoxycarbonyl-1-ethyl-6-fluoroquinolin-4(1H)-one and novel perspective triazolopyrimidines has been developed. This procedure features mild conditions a broad substrate scope including hydrophobic hydrophilic triazolopyrimidines. The synthesized structures combine fragments fluoroquinolone with proved antibacterial activity triazolopyrimidines, which may act as structural analogs adenosine receptor effectors or antiviral azoloazine heterocycles.